Thesis: Experimental-Computational Approaches to Identify Synergistic Effects of Anti-Cancer Drugs (2019).

As a part of the COLOSYS project, my PhD project has the higher aim of validating and refining the model(s) used for making predictions of cellular response to combined targeted therapy. This validation process partly relies on a high-throughput cell line screening platform, which will be developed and optimized during the course of the project. The drug combinations held to be the most promising ones in high-throughput cell line screens will be further tested and validated in 3D/in vivo models during later stages of my PhD project.

To enable generation of reliable drug predictions and applying these predictions at a personalized level in the future, the computational models continuously need to be refined with validation data. The validation process being a part of my PhD project is therefore an important step in bringing the computational models closer to the clinic.